Spironolactone 17 alpha hydroxylase

Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia. Spironolactone and/or its metabolites have been found in vitro to weakly inhibit a broad array of steroidogenic enzymes including cholesterol side-chain cleavage enzyme, 17α-hydroxylase, 17,20-lyase, 5α-reductase, 3β-hydroxysteroid dehydrogenase, 11β-hydroxylase, 21-hydroxylase, and aldosterone synthase (18-hydroxylase)

2024-03-29
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  1. INTRODUCTION
  2. As our patient is a female, eplerenone would have no indication
  3. Gov't, P
  4. CYP17A1
  5. Her symptoms improved greatly
  6. S
  7. Baseline hormonal studies showed low
  8. Peter M, Sippell WG, Wernze H
  9. Endocrinology