This activity reviews the indications, action, and contraindications for loratadine as a valuable agent in treating and managing allergic rhinitis and urticaria
Those who developed significant back or leg bone pain (SP) were enrolled into the treatment stage (TRT) and randomized to daily loratadine 10 mg or placebo for 7 days
Abstract
Abstract Aims Breast cancer patients on chemotherapy who receive pegfilgrastim to prevent neutropenia may experience severe bone pain as a side effect
This pilot study aimed to ascertain if bone pain induced by granulocyte-colony stimulating factors (G-CSFs) can be alleviated or eliminated by oral antihistamine
Drug: Loratadine
We evaluated the effect of prophylactic naproxen or loratadine vs no prophylactic treatment on pegfilgrastim-associated bone pain
Placebo capsule, administered initially 3 hours before the first dose of G-CSF in the autologous stem cell mobilization protocol, and then daily for a minimum of 8 days
Pegfilgrastim-associated bone pain occurred in 19% and loratadine was the most common medication used to treat it
Histamine has been suggested as a chemical mediator Tumor cells release factors that stimulate osteoclastic and osteoblastic activity, disrupting the balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation and repair
4%, 59
The mechanisms of bone pain secondary to G-CSFs are not fully known, but research has shown that histamine release is involved in the inflammatory process
This is not a complete list of side effects and others may occur
(2019) Oral loratadine in the management of G-CSF bone pain: a pilot study
Fig 3
Randomized phase II study of loratadine for the prevention of bone pain caused by pegfilgrastim
The incidence of bone pain was 45% (n = 30) in our sample, but more than half (n = 45; 69%) of the women took either acetaminophen, NSAIDs, or loratadine alone or in combination to prevent bone pain
In both cases I took it few days before through few days after and had very significant pain With intravenous bisphosphonates